摘要
目的 研究杉木的萜类化学成分。方法 通过乙醇提取,乙酸乙酯萃取,再结合各种柱色谱方法对乙酸乙酯部位进行了系统的分离,并根据理化性质和光谱数据鉴定化合物的结构。结果 分离并鉴定了9个萜类化合物的结构, 8(17),12E,14-labdatrien-18-al (1)、4S,5R,9S,10R-8(17),12,14-labdantrien-18-ol acetate (2)、4S,5R,9S,10R-8(17),12,14-labdantrien-18-ol (3)、4S,5R,9S,10R-8(17),12,14-labdantrien-18-oic acid (4)、3β-hydroxy-8(17),13E-labdandien-15-oic acid (5)、hinokiol (6)、8,15-pimaradien-18-oic acid (7)、15-nor-14-oxo-8(17), 12-labdandien-18-oic acid (8)和15-nor-14-oxo-8(17),12-labdan-dien-18-ol (9)。结论 化合物1、2、5~7和9为首次报道从该植物中分离得到。
Abstract
OBJECTIVE To study the terpene constituents from Cunninghamia lanceolata (Lamb.) Hook. METHODS The ethanol crude extract was fractionalized by using EtOAc, then a series of chromatography methods were used to isolate the terpene compounds and the structures were elucidated by their physicochemical properties and spectroscopic data. RESULTS Nine terpenes were isolated and identified as 8(17),12E,14-labdatrien-18-al (1), 4S,5R,9S,10R-8(17),12,14-labdantrien-18-ol acetate (2), 4S,5R,9S,10R-8(17),12,14-labdantrien-18-ol (3), 4S,5R,9S,10R-8(17),12,14-labdantrien-18-oic acid (4), 3β-hydroxy-8(17),13E-labdandien-15-oic acid (5), hinokiol (6), 8,15-pimaradien-18-oic acid (7), 15-nor-14-oxo-8(17), 12-labdandien-18-oic acid (8), and 15-nor-14-oxo-8(17),12-labdan-dien-18-ol (9). CONCLUSION Compounds 1, 2, 5-7 and 9 are isolated from this plant for the first time.
关键词
杉木 /
萜类 /
化学成分
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Key words
Cunninghamia lanceolate /
terpene /
chemical constituent
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郭婷,董莉,魏秀丽,何峰,黄家宇.
杉木的萜类化学成分研究[J]. 中国药学杂志, 2016, 51(15): 1278-1281 https://doi.org/10.11669/cpj.2016.15.004
GUO Ting, DONG Li, WEI Xiu-li, HE Feng,HUANG Jia-yu.
Terpene Constituents from Cunninghamia lanceolate[J]. Chinese Pharmaceutical Journal, 2016, 51(15): 1278-1281 https://doi.org/10.11669/cpj.2016.15.004
中图分类号:
R284
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参考文献
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脚注
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